• br Conclusions In this study

  2022-04-18

  

  Conclusions In this study, we discovered that the G-quadruplex (Q1) formed by S1 sequence in the upstream region of the transcription start site of c-Myb gene functioned as a positive transcriptional regulator, which was different from the most cases that G-rich sequences functioned to impair the

• In the upper part of the intestine a small

  2022-04-18

  

  In the upper part of the intestine a small amount of conjugated BAs are reabsorbed via passive diffusion, whereas the part of BAs that escape enterohepatic circulation passes into the colon where they undergo bacterial conversions such as deconjugation, dehydroxylation or dehydrogenation, into secon

• The ability to metastasize is the

  2022-04-18

  

  The ability to metastasize is the defining character of a cancer and the leading cause for resultant mortality. It is hypothesized that a rare subset of cancer cells, often operationally referred to as “cancer stem cells” (CSCs), are responsible for sustaining cancer metastasis and recurrence [1]. T

• With the increasing use of INSTIs in clinical practice drug

  2022-04-16

  

  With the increasing use of INSTIs in clinical practice, drug resistance to this class in different HIV-1 subtypes should be carefully monitored and investigated. Studies on HIV-1 diversity and drug resistance would greatly help our understanding of viral transmission, pathogenesis and ART resistance

• br Introduction Erythropoietin EPO is a glycoprotein hormone

  2022-04-16

  

  Introduction Erythropoietin (EPO) is a glycoprotein hormone and the principal stimulator of erythropoiesis (Jelkmann, 2011). EPO promotes the proliferation and differentiation of red blood cells, which is important for oxygen transport. Low EPO levels in blood cause anemia; however, excessive lev

• The strict control of Spi expression is critical for

  2022-04-16

  

  The strict control of Spi1 expression is critical for proper myeloid cell fate determination, and genetic or epigenetic changes in the Spi1 gene frequently contribute to the leukemogenesis in mice and human. It is has been shown that Spi1 expression is frequently downregulated in human AML patients

• The site of metastasis in breast cancer often contributes

  2022-04-16

  

  The site of metastasis in breast cancer often contributes to the patient’s OS. Patients with bone metastasis from their breast cancer often have a notably increased survival over patients with visceral or I-BET-762 metastasis. In this analysis, ER+/HER2+ patients were noted to have a higher rate of

• In summary we propose a

  2022-04-16

  

  In summary, we propose a model that explains the possible mechanism the HULC mediates activation of HBV in liver cancer Eltrombopag Olamine (Fig. 8). In the model, HULC promotes the expression of miR-539 by stimulating HBx-co-activated STAT3. Then, miR-539 down-regulates APOBEC3B, leading to an inc

• Amikacin disulfate The neotropical fish Prochilodus lineatus

  2022-04-16

  

  The neotropical fish Prochilodus lineatus has been widely used in experimental designs for being sensitive to variations in water quality and tolerant to laboratory conditions (Camargo and Martinez, 2006, Cazenave et al., 2014, da Silva and Martinez, 2014, Vieira et al., 2016). Concern and reports a

• br Introduction The discovery that the nitric oxide NO

  2022-04-16

  

  Introduction The discovery that the nitric oxide (NO), soluble guanylate cyclase (sGC), and cyclic guanosine monophosphate (cGMP) pathway mediates erection has led to the use of phosphodiesterase type 5 (PDE-5) inhibitors as the gold standard for treating erectile dysfunction (ED) through the inh

• br Pathophysiology of glaucoma Glaucoma is

  2022-04-16

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their LCQ-908 in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes in visual acuity and evidenc

• br Conclusion GST expression was detected in the Hemicornea

  2022-04-16

  

  Conclusion GST expression was detected in the Hemicornea construct and the commonly used animal cornea models at both the protein and functional levels. The results are summarized in Table 1. However, the construct exhibited lower levels of activity of GST, a marker of phase II enzymatic activity

• Consistent with other studies on

  2022-04-16

  

  Consistent with other studies on the metabolic effects of an OM3 enriched diet [26,104,105], irrespective of gender, the lowest glucose levels were seen in the Bob-Cat groups fed OM3 diet. Sexual dimorphism was observed in insulin levels. The highest average levels were in the HFD fed [Tg(CAT)±] mal

• The GLU Epac transgenic mouse enabled us

  2022-04-16

  

  The GLU-Epac transgenic mouse enabled us to monitor cAMP responses to GPR119 ligands in individual primary cultured L-cells. Not all L-cells were found to be responsive to AR231453, suggesting there may be a subpopulation of L-cells that do not express functional GPR119. There was a tendency for sma

• Adenosine triphosphate ATP is thought to be a

  2022-04-16

  

  Adenosine triphosphate (ATP) is thought to be a crucial molecule in acute pain signaling in the DRG, as well as in the development and maintenance of chronic pain (Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). Extracellular ATP activates the ionotropic P2X receptors (Bur

11194 records 151/747 page Previous Next First page 上5页 151152153154155 下5页 Last page