• br Conclusion Discovery of an ideal orally active

  2022-08-03

  

  Conclusion Discovery of an ideal orally active antithrombotic drug has remained elusive till date. Research efforts in this direction led to the discovery of numerous coagulation enzyme inhibitors including various thrombin and FXa inhibitors. Several preclinical studies have highlighted the impo

• br Experimental procedures br Results br Discussion The data

  2022-08-03

  

  Experimental procedures Results Discussion The data herein confirm the well documented neuroinflammatory effect of TLR3 activation following systemic administration of the viral mimetic poly I:C and the associated acute sickness response which includes fever, reduced body weight and allodyn

• Tyr phosphorylation of AnxA was first reported

  2022-08-03

  

  Tyr23 phosphorylation of AnxA2 was first reported to be involved in endocytosis, particularly in the internalisation of the insulin receptor [20]. Phosphorylated Tyr23 seems to be necessary for the stable association of AnxA2 with endosomes, and for their early-stage transport [14]. The role of AnxA

• br Conflict of interest br

  2022-08-03

  

  Conflict of interest Acknowledgements This work was funded by the University of Turin (ex60% 2014), World Wide Style Project (WWS; University of Turin/Fondazione CRT) and University of Florence (ex60% 2014). ACR and AP designed the study; AP, EB and IO conducted the literature search and analy

• autophagy pathway In the present study fasting

  2022-08-03

  

  In the present study, fasting blood glucose and insulin levels were not significantly different between GA patients and control cases. Normal mammalian cells typically acquire fatty acids from the circulation owing to insulin, which is the most lipogenic hormone in the subset of adult tissues, inclu

• Here we performed TEM and AFM

  2022-08-02

  

  Here, we performed TEM and AFM imaging to study APE1–DNA interactions. The results showed that APE1 can dynamically polymerize on DNA in an apparently sequence-independent manner. We propose that this protein polymerization allows for scanning of the structural properties of DNA with short residence

• The current study also inferred that MT content in Crassostr

  2022-08-02

  

  The current study also inferred that MT content in Crassostrea gigas might be associated with the Cd level, and can be affected by MT turnover. The a short text of MT in cytosol is beneficial for aquatic organisms to adapt the seawater contaminated by heavy metals, and MT is a biomarker for marine

• Introduction l Glutamate is a major excitatory neurotransmit

  2022-08-02

  

  Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is

• Long non coding RNAs lncRNAs are mRNA like

  2022-08-02

  

  Long non-coding RNAs (lncRNAs) are mRNA-like transcripts of greater than 200 nucleotides (nt), with little or no protein-coding potential [13,14]. LncRNAs have been suggested to participate in transcription and post-transcription regulation as scaffolds, guides, decoys or repressors, activators, and

• In the absence of HH ligand

  2022-08-02

  

  In the absence of HH ligand, HH signaling is actively maintained in a repressed state by the activity of the HH receptor Patched (PTCH). PTCH is a 12-transmembrane domain protein whose intracellular localization is concentrated at the BMS345541 hydrochloride of the primary cilium, a single antenna-

• Introduction Since the development of

  2022-08-02

  

  Introduction Since the development of the first radioimmunoassay (RIA) to measure hormone levels in the late 1950s, for which Rosalyn Sussman Yalow was awarded the Nobel Prize for Medicine in 1977 (the second woman ever receiving it), the use of methylguanine dna methyltransferase in molecular rese

• In conclusion our results show that multiple

  2022-08-02

  

  In conclusion, our results show that multiple receptor populations can be expressed when α4, β3 and δ mRNAs are injected into Xenopus oocytes and include β3 homomeric; α4β3; and β3δ receptors. The previously unidentified β3δ can be differentiated pharmacologically from either β3, α4β3 and α4β3δ rece

• Brain derived neurotrophic factor BDNF is the most abundant

  2022-08-02

  

  Brain-derived neurotrophic factor (BDNF) is the most abundant growth factor in the brain and is critical for neuronal development and synaptic plasticity (Bekinschtein et al., 2008; Lu et al., 2014). Besides playing an important role in mood and cognition, BDNF is also involved in the regulation of

• The presence of FBP in nuclei seems to

  2022-08-02

  

  The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas

• br Application of TIRFM to visualizing exocytosis TIRFM

  2022-08-02

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin WEHI-539 hydrochloride australia (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as ma

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