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br Funding The research for this paper is conducted
2021-12-20
Funding The research for this paper is conducted as part of a PhD thesis at Pasteur Institute of Iran and it was financially supported by Pasteur Institute of Iran and the Iranian Centre for Communicable Diseases. Conflict of interest Acknowledgments Introduction The viral enzyme integ
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brompheniramine maleate receptor To identify genes with sign
2021-12-20
To identify genes with significant brompheniramine maleate receptor differences, we performed differential gene expression analysis between the two individuals with TRRAP variants (combined as biological replicates) and two unaffected controls. Gene ontology (GO) enrichment analysis of these genes
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Although we showed that RBL H Sc cells took
2021-12-20
Although we showed that RBL-2H3 Sc98 racecadotril took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, including S
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69 8 Compared with the tetrazole derivative the
2021-12-20
Compared with the tetrazole derivative , the potency of analogs – was 3- to 17-fold improved. Of the range of heterocycles prepared, 1,2,4-thiadiazol-5(4)-one and 1,3,4-oxadiazol-2(3)-one showed the best potencies of 0.52μM and 0.61μM, respectively. Introduction of a second hydrogen bond donor, su
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In contrast to RhoA Rac and Rap which are
2021-12-20
In contrast to RhoA, Rac1 and Rap1 which are stimulated by platelet activators and inhibited by NO/PKG, the GTPase ADP-ribosylation factor 6 (Arf6) is regulated in the reverse way. Platelet agonists like thrombin, collagen, or ADP, reduce Arf6-GTP levels, whereas NO and PGI2 oppose this reduction [1
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L 012 sodium salt Financial nonfinancial disclosures The aut
2021-12-20
Financial/nonfinancial disclosures: The authors have reported to CHEST the following: M. J. A. has received investigator-initiated grants from Pfizer and Boehringer Ingelheim for unrelated research. None declared (X. D., S. C. D., G. B., N. T. W., J. L. P., J. H., B. E., A. J. L., J. A. B., C. S., C
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Milligan et al demonstrated the important role of TNF IL
2021-12-20
Milligan et al. [31] demonstrated the important role of TNF-α, IL-6 and IL-1β in the development of mechanical hyperalgesia induced by intrathecal injection of gp120. Because of this work, we decide to produce and purify gp120 to develop biological systems to study pain and behavior in rodents. Intr
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One of the main clinical issues of
2021-12-20
One of the main clinical issues of ABCB1, together with its impact on intestinal absorption, concerns its location at the BBB. Indeed, ABCB1 has been identified in the luminal side of endothelial cells and in the abluminal side of astrocyte endfeet processes of the CNS microvasculature [[36], [37],
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The identification of distinct expression domains in the
2021-12-20
The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category
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br Ghrelin Ghrelin was purified from rat stomach about
2021-12-20
Ghrelin Ghrelin was purified from rat stomach about twenty years ago as a 28-amino UNC0638 octanoylated peptide and shown to be the endogenous ligand of the growth hormone (GH) secretagogue receptor (now termed GHSR1a, Howard et al., 1996, Kojima et al., 1999). GHSR1a is a 7-transmembrane recepto
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Though regulation of ghrelin interaction with
2021-12-20
Though regulation of ghrelin interaction with GHSR has not been described previously, a precedent for a similar regulatory mechanism exists in the form of the interaction between Agouti-Related Protein (AgRP) and melanocortin receptor subtypes MC3R and MC4R (Ollmann, 1997). AgRP is produced by hypot
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The multiple sequence analysis showed that the putative amin
2021-12-20
The multiple sequence analysis showed that the putative amino 4-HQN sequence of HbFDP had 80–99% identity to the FDPs from H. brasiliensis, Lupinus and T. wilfordii, Malus×domestica, Centella asiatica, M. sativa, M.recutita, accession H. annuus, and A. thaliana. The present results are in agreement
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S63845 Arena Pharmaceutical introduced a biaryl sulfone
2021-12-20
Arena Pharmaceutical introduced a biaryl sulfone derivative with antagonistic activity at H3Rs known as APD-916, ((R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine), which was rationally designed from corresponding sulfonamides in order to yield compounds with short dura
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7441 synthesis A revolution in cancer immunotherapy has rece
2021-12-20
A revolution in cancer immunotherapy has recently emerged with the development of novel immunomodulatory antibodies, classified as immunostimulatory agonist monoclonal 7441 synthesis (mAbs) or checkpoint blocking mAbs. CD40/CD40L, as an important costimulatory pathway, mediates a broad spectrum of
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Interestingly systemic circulating levels of NOx were not
2021-12-18
Interestingly, systemic circulating levels of NOx were not dramatically increased by treatment with isosorbide mononitrate or sodium nitrite at a dose which exerted beneficial effects on the progression of PH. In line with our results, Mathew et al. [13] demonstrated that the long-acting NO donor mo
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