• In silico analysis revealed structural similarities between

  2021-10-27

  

  In silico analysis revealed structural similarities between the CpMutY and the EcMutY which share typical domains and structural motifs (Fig. 5), common to a wide range of structurally related DNA repair enzymes. These include an endonuclease III domain, involved in excision of damaged pyrimidines,

• Structural analysis of the MD open state

  2021-10-27

  

  Structural analysis of the MD-open state unveils that the transmembrane domain features a symmetric organization of the pore-lining helices M2 similar to the semi-open structure but with a local asymmetry at the constriction point, which is critical for chloride permeation. The atomistic simulations

• Ionotropic glutamate receptors GluRs are ligand gated ion

  2021-10-27

  

  Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio

• br Conflict of interest br Transparency

  2021-10-27

  

  Conflict of interest Transparency document Acknowledgements We acknowledge our funding sources from the American Heart Association (13EIA4480016) and the National Institute of Health/National Heart, Lung, and Blood Institute (RO1 HL094414). We are very grateful to Dr. Shaohua Xiao and Dr. S

• In an immunohistochemical analysis of gastric cancer

  2021-10-27

  

  In an immunohistochemical analysis of 117 gastric cancer samples, reduced Cx43 and E-cadherin expression were shown to contribute to the development of primary gastric cancer; however, increased Cx43 and E-cadherin expression contributed to lymph node metastasis [13]. In primary urothelial BMS 19388

• br During cardiac ischaemia a decrease in

  2021-10-27

  

  During cardiac ischaemia, a decrease in GJ coupling is observed, which results in slower conduction of electrical impulses and a higher risk of arrhythmias.[13], [20] In Huntington’s disease an increase in the igf ir of 5 Cxs was observed in the astrocytes in the brain, suggesting an adaptive pro

• Although domain organization had been clearly delineated by

  2021-10-27

  

  Although domain organization had been clearly delineated by the 4.3-Å structure of T4-γ-secretase [], atomic modeling of the side chains had to wait for the 3.4-Å structure []. In total, 598 residues in the transmembrane region and 632 residues in the ECD were modeled for the four components of huma

• The GABA A receptors containing

  2021-10-27

  

  The GABA-A receptors containing the δ subunit are crucial for the mediation of non-synaptic inhibition in the dentate gyrus; thus, the decreased expression of the δ subunit may suggest a decrease in the inhibitory tone and an increase in the neuronal excitability. Moreover, the GABA-A receptors cont

• The G protein coupled receptor GPR also

  2021-10-27

  

  The G protein-coupled receptor, GPR40 (also called FFAR1) responds to medium and long chain unsaturated fatty acids, resulting in increase of insulin secretion during elevated glucose levels. The glucose dependency of insulin secretion makes this receptor a very good target for developing therapies

• The normal function of the

  2021-10-27

  

  The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa

• br Conclusion In conclusion rats in this model

  2021-10-27

  

  Conclusion In conclusion, rats in this model of HELLP syndrome demonstrated increased placental and circulating FasL and increased placental Fas when compared to NP rats. Administration of an ETA receptor antagonist to HELLP rats tended to decrease circulating FasL and placental Fas, while not af

• AD is a major neurological disorder usually effecting

  2021-10-27

  

  AD is a major neurological disorder, usually effecting the elderly population, which is difficult to diagnose until symptoms begin to accumulate. As of 2013, approximately five million Americans were living with AD. The number with this disease is projected to be 16 million by 2050 (Hebert et al., 2

• Our results further indicate that low expression of p CBP

  2021-10-27

  

  Our results further indicate that low expression of p300/CBP in CRC is directly associated with poor clinical therapeutic outcome of 5-FU treatment, potentially providing a new set of biomarkers to predict chemo-sensitivity. Although the ability of low expression of p300/CBP to predict poor prognosi

• br Conclusion The wild study reports seasonal variations

  2021-10-26

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and BET bromodomain inhibitor plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher no

• 86002 In this sense feline females

  2021-10-26

  

  In this sense, feline females are coitus-induced ovulators and regardless they get pregnant or not, serum progesterone levels increase over 1.5 ng/ml once ovulation has occurred [42]. On the other hand, queen embryos reach the uterus on days 6–8.5 after coitus [29]. Due to their small size, embryos

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