• Ligand binding RTK activation induces the endocytic

  2021-03-03

  

  Ligand binding (RTK activation) induces the endocytic internalization of RTKs, and this has been demonstrated for CSF-1R [15], [16], [17]. Endocytosed RTKs are targeted to the lysosome, which we and others have established to be dependent on ubiquitination via CBL-family and recognition by ESCRT com

• In this study we characterized the metabolic function of tra

  2021-03-03

  

  In this study, we characterized the metabolic function of tra2 in the Drosophila fat body. Similar to the 9G8 phenotype, decreasing tra2 levels in the Drosophila fat body using RNAi resulted in increased starvation resistance and a large increase in triglycerides. This increased storage of triglycer

• Due to its several industrial applications the

  2021-03-03

  

  Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian iMDK (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 2003) and y

• Introduction Hepatocarcinoma is a common

  2021-03-02

  

  Introduction Hepatocarcinoma is a common and aggressive form of cancer (Trad et al., 2017). Due to a high rate of postoperative recurrence and metastasis, the prognosis for HCC remains dismal (Wang et al., 2017a, 2017b). Subclinical metastasis is the major cause responsible for tumor recurrence and

• br Conclusions br Conflicts of interest

  2021-03-02

  

  Conclusions Conflicts of interest Research funding This work was financially supported by Shanghai Committee of Science and Technology (No. 16431903800). Main Text Developmental processes make usage of a surprisingly limited number of morphogens and signaling components to control a ple

• Information on the mechanism by which parasite infections

  2021-03-02

  

  Information on the mechanism by which parasite infections promote ECM degradation is limited (McKerrow et al., 1983; Andrade, 1994; Lu and Lai, 2013; Thibeaux et al., 2014). The interaction of plasminogen-plasmin with proteins of microorganisms, including bacteria, has been suggested to play a key r

• br Protein protein interactions of LEI L DNase II

  2021-03-02

  

  Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino L 006235 substitution in the RSL can led to the inhibition of a totally different protease. W

• In the present study we used

  2021-03-02

  

  In the present study, we used linagliptin, one of the commercially available DPP-4 inhibitors, because it has more long-lasting inhibition of DPP-4 activity than other drugs of this class. We hypothesized that linagliptin may interact with intercellular components, not only with DPP-4 on the plasma

• To date many studies have reported

  2021-03-02

  

  To date, many studies have reported significant aberrant methylation patterns in TIMPs in various types of cancer Ro 3306 [[16], [17], [18]]. However, little has been reported on the events that lead to the methylation of TIMPs in the UV-irradiated human skin. Therefore, the objective of this study

• br Introduction The endeavor to

  2021-03-02

  

  Introduction The endeavor to achieve a successful use of commercial-off-the-shelf (COTS) electronic devices in space is not new and the reasons are well known [1], [2], [3]. More recently, COTS have been widely employed in the manufacturing of low-cost, small satellites, for scientific and even c

• Determination of relative potency EC

  2021-03-02

  

  Determination of relative potency (EC50) by dose response assays in vitro is subject to the same sources of variability as determination of affinity, since the EC50 and Hill slope of the dose response curve are highly dependent on the binding of ligand to a competing receptor that may be present, an

• The Nile tilapia Oreochromis niloticus is an important farme

  2021-03-01

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• The TELI results of DNA

  2021-03-01

  

  The TELI results of DNA damage responses to CAA and SO then informed our choice of bacterial strains in subsequent experiments. We investigated E. coli cellular survival in response to CAA and SO exposure by determining the sensitivity of a number of E. coli strains, each possessing single or multip

• A 419259 trihydrochloride Interest in DGKs increased as

  2021-03-01

  

  Interest in DGKs increased as it became clear that not only are they important for lipid homeostasis, they serve to modulate the relative levels of diacylglycerol (DAG) and phosphatidic A 419259 trihydrochloride (PtdOH) that play critical roles in a variety of signaling pathways (Eichmann and Lass,

• The compounds were ranked based

  2021-03-01

  

  The compounds were ranked based on the Glide XP Score, as shown in . All 15 compounds were subject to a radiometric assay previously used in our lab to evaluate their ability to inhibit DHFR steady-state activity in recombinant TS-DHFR (A). Compound demonstrated greater than 50% inhibition of DHFR

15548 records 683/1037 page Previous Next First page 上5页 681682683684685 下5页 Last page