• br Discussion Our results confirm that germline variations

  2019-05-05

  

  Discussion Our results confirm that germline variations in the TPMT gene are associated with treatment outcome in children with ALL [5]. The ability of TPMT to catalyze S-methylation and inactivate 6-mercaptopurine makes it a major determinant of 6-mercaptopurine toxicity. Furthermore, reduced TP

• FGF is a member of

  2019-05-04

  

  FGF21 is a member of the FGF family. It is preferentially expressed in the liver and is inducible in adipose tissue. As an insulin-sensitizing metabolic regulator, it stimulates lysophosphatidic acid uptake by adipocytes and also targets the central nervous system. FGF21 treatment corrects diet-ind

• El cap tulo siguiente La vanguardia

  2019-05-04

  

  El capítulo siguiente (“La vanguardia requisada. Octavio Paz y el surrealismo”, 57–76) está dedicado S63845 la valoración del surrealismo, que Paz plantea después de su vuelta a México a principios de los años cincuenta (, el ensayo “El surrealismo”, incluido en , algunos fragmentos de ). Es sabido

• La presencia de este rbol americano detiene

  2019-05-04

  

  La presencia de este árbol americano detiene la marcha del desterrado europeo y transforma su mirada exótica en mirada unificadora y productiva sobre el espacio americano. La subversión que realizan los traductores americanos consiste en quitarle a la naturaleza americana cualquier rastro de exotism

• Es el propio C ndido quien coloca en relaci

  2019-05-04

  

  Es el propio Cándido quien coloca en relación lenguaje literario y lenguaje plástico, palabra y trazo. ¿Será coincidencia que lo primero que resalta en el Autorretrato de 1957 (figura 2) sean esos trazos que atraviesan la figura del pintor? Recordemos la forma en que Ramos se refiere Phenformin su r

• Aside from this report only two other studies of dexrazoxane

  2019-05-04

  

  Aside from this report, only two other studies of dexrazoxane use in adult AML patients have been published. In a series of seven patients with AML, Lemez and Maresova reported that the administration of dexrazoxane 30min before daunorubicin (dose 8-13x higher than daunorubicin) or mitoxantrone (dos

• MiR a rs is situated in

  2019-05-04

  

  MiR-196a2 rs11614913 is situated in the 3′ passenger strand mature sequence of miR-196a2. The C to T mutation of the rs11614913 SNP, which was located in the stem region of an miR-196a-2 precursor, leads to a change from a G:C to a G:U mismatch. A previous study has shown that miR-196a2 rs11614913 c

• Al mismo tiempo que el joven no

  2019-04-30

  

  Al mismo tiempo que el joven no cree en la matanza, actualiza antiguos estereotipos reforzados por imágenes que construyen el imaginario social. ¿Qué otra cosa hace Altunaga, sino problematizar la axiología revolucionaria del fin del racismo cuando pone en boca del barrendero la siguiente reflexión?

• The deletion of q seen

  2019-04-30

  

  The deletion of 14q seen in our patient included the IGH locus at 14q32.33. This is noteworthy, because loss of 14q has been reported as a recurrent aberration acquired during the natural history of CLL. The acquisition of a del(14) may thus be indicative of CLL in transformation. In a study of a la

• br In a detailed analysis using multiple

  2019-04-30

  

  In a detailed analysis using multiple data sources in this issue of , Emily Keats and colleagues show that Kenya made some progress in reducing maternal and newborn mortality between 2003 and 2015, and made greater progress in reducing child mortality between 1998 and 2015, after earlier increases

• br More than any other disease group injuries chart

  2019-04-30

  

  More than any other disease group, injuries chart the story of a country\'s development in real time. China has seen major changes in injury causes and risks over the past three decades attributable to rapid urbanisation, motorisation, and occupational shifts, as well as health reforms and demogra

• br Ablation strategies from targeted to homogenization The t

  2019-04-30

  

  Ablation strategies – from targeted to homogenization The techniques and principles originally developed in postinfarction scar have been translated and applied to patients with various etiologies of fibrosis and confluent scar including Chagasic cardiomyopathy, nonischemic cardiomyopathy, arrhyt

• La propia Mirna Paiz rescata en sus

  2019-04-30

  

  La propia Mirna Paiz rescata en sus memorias cuál fue su papel en la guerrilla, dejando claro que si bien en algunas ocasiones tuvo PX-478 2HCl su cargo la administración y distribución de medicinas, su labor no era ser costurera. La decisión editorial de cubrir su rostro e incluso excluirla del ún

• People in LMICs are disproportionately exposed to severe

  2019-04-30

  

  People in LMICs are disproportionately exposed to severe acute kidney injury and have substantially less access to effective treatment than do people in higher-income countries. Framing acute kidney injury as a driver of substantial inequity in disease risk and mortality in low-resource countries, t

• La dictadura militar guatemalteca de difiere

  2019-04-29

  

  La dictadura militar guatemalteca de 1982-1985 difiere de la anterior (1963-1966), ya que asumió un papel transformador y fundacional. Al igual que el golpe militar argentino del 24 de marzo de 1976, el golpe del 23 de marzo de 1982 se produjo cuando la crisis política, social y económica, una crisi

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