Archives
- 2018-07
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
- 2024-10
- 2024-11
-
In normal cells the apoptotic stimuli lower
2020-06-11
In normal cells, the apoptotic stimuli lower the expression level of antiapoptotic proteins by increasing turnover rate and preventing the constant degradation of proapoptotic proteins. Thus, the dysregulation of anti-/pro-apoptotic proteins will confer the survival of cancer Pentamidine via enhanc
-
Contrary to the profuse dopaminergic innervation of the
2020-06-11
Contrary to the profuse dopaminergic innervation of the thalamus found in human and non-human primates (Brown et al., 1979, Sanchez-Gonzalez et al., 2005), in rodents, the RTn is one the few thalamic nuclei that receives dopaminergic input (Anaya-Martinez et al., 2006, Garcia-Cabezas et al., 2007, G
-
For this reason we hypothesized that the
2020-06-11
For this reason we hypothesized that the DHFR gene could be a potential candidate in clefting. Our data, obtained using a family-based association approach, evidenced an association with borderline significance for the SNP rs1677693. The variant allele A at this marker seems to reduce the risk of C
-
Cryptotanshinone In the present study we investigated the
2020-06-10
In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G
-
In the present study the A
2020-06-10
In the present study, the A/P ratio in the MCF-7 cell line was significantly increased by the combination of 1 nM E2 and progestogens, except P4, as well as by10 nM E2 combined with NET. The similar findings were also noted by several reports [16], [17], [18], [19], [20] in which progestogens combin
-
In this work we fabricated a kind of multifunctional nanopar
2020-06-10
In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic CPTH2 hydrochloride copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR
-
unless EP is the major receptor to mediate PGE
2020-06-10
EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by unless in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pain [3], [16], [26]. However, the
-
br O GlcNAc transferase OGT belongs to the metal independent
2020-06-10
O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t
-
Approximately of the etamicastat dose was recovered in urine
2020-06-10
Approximately 50% of the etamicastat dose was recovered in urine, 30% in the form of etamicastat and 20% in the form of BIA 5-961. These data agree with those from a study with [14C]-labeled etamicastat in healthy subjects, which showed that approximately 95% of the administered radioactivity had be
-
gli protein We elucidated that the ten DGK isozymes have dif
2020-06-10
We elucidated that the ten DGK isozymes have different relative 1-MGK and 2-MGK activities vs DGK activity under the same conditions. However, because the octylglucoside-mixed micellar assay was developed for DGK, it is not known whether the DGKs exhibit maximum 1-MGK and 2-MGK activities in this as
-
br Conclusion br Limitations br Conflict of interest
2020-06-10
Conclusion Limitations Conflict of interest Financial disclosure The research was supported by National Institute of Mental Health and Neuro Sciences (NIMHANS)Intramural Research Grant ID NIMH/PROJ-RSM/545/2014-15. India. Acknowledgments Introduction Increased central and peripher
-
Henderson et al reported that allergen induced airway remode
2020-06-10
Henderson et al. [20] reported that allergen-induced airway remodeling was blocked by the CysLT1 receptor antagonist montelukast. The development of epithelial thickening and mucus accumulation at relatively small Sulfo-NHS-LC-Biotin was also suppressed by montelukast. The CysLT2 receptor antagonist
-
At ngL DEX did not affect
2020-06-10
At 3000ngL−1, DEX did not affect our investigated parameters, suggesting that DEX is regulated by CYP450 in a biphasic way, a response to xenobiotics that is not uncommon (Heinrichs et al., 1994). These data might also suggest that fish adapted to DEX exposure. It was previously shown that, dependin
-
DBeQ Introduction Cyclin dependent kinases CDKs are a family
2020-06-10
Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as DBeQ and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-like re
-
The period of status survived before transition and
2020-06-10
The s3i of status survived before transition and its censorship were required to be identified. Referring to the extracted data set in Table 1, the system started to operate at 10:30 with the status 1111 and then changed to the status 1112 at 12:00. The period for the transitional status 1111→1112
14860 records 771/991 page Previous Next First page 上5页 771772773774775 下5页 Last page